Masjid Ali Ibn Abi Talib is a historic mosque in the southwestern part of Madinah. It is believed to be one of the places where the Prophet Muhammad (peace be upon him) prayed on special occasions.

The mosque was first built during the rule of Caliph Al-Walid ibn Abd al-Malik. At that time, Omar ibn Abd al-Aziz, the governor of Madinah (706–712 CE), ordered the construction of all mosques where the Prophet had prayed. The mosque has been rebuilt and renovated many times during the Saudi era.